Oxygen-derived free radicals and postischemic myocardial dysfunction (“stunned myocardium”)
نویسندگان
چکیده
منابع مشابه
The stunned myocardium: prolonged, postischemic ventricular dysfunction.
Myocardial ischemia has, for many decades, been viewed as an all-or-none process that causes myocardial necrosis when prolonged and severe, but whose effects are transient when it is brief or mild. In view of the evidence that the ischemic process may "hit, run and stun," perhaps our thinking about the consequences of myocardial ischemia should be expanded. According to this formulation, an isc...
متن کاملDirect evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog.
Electron paramagnetic resonance (EPR) spectroscopy was used to investigate whether (i) the free radicals produced in the "stunned" myocardium (myocardium with postischemic contractile dysfunction) are derived from O2, (ii) inhibition of radical reactions improves function, and (iii) i.v. spin traps are effective. Open-chest dogs undergoing a 15-min coronary occlusion received an i.v. infusion o...
متن کاملNicotine exacerbates postischemic contractile dysfunction of 'stunned' myocardium in the canine model. Possible role of free radicals.
BACKGROUND There is no doubt that high doses of nicotine have deleterious effects on cardiovascular function. However, the effects of lower and more clinically relevant doses of nicotine have received little attention, and the consequences of nicotine in the setting of ischemia/reperfusion are virtually unknown. The first objective of this study was to determine whether nicotine, given either b...
متن کاملAttenuation of dysfunction in the postischemic 'stunned' myocardium by dimethylthiourea.
The mechanism for the prolonged contractile dysfunction observed in myocardium reperfused after reversible regional ischemia ("stunned" myocardium) is unclear. Recent studies suggest that myocardial stunning may be mediated by oxygen-derived free radicals, but the precise molecular species involved remain unknown. Thus we explored the role of the highly cytotoxic hydroxyl radical in regional po...
متن کاملThallium 201 kinetics in stunned myocardium characterized by severe postischemic systolic dysfunction.
The hypothesis tested in this study was that despite the presence of severe postischemic myocardial dysfunction ("stunning"), the extraction and subsequent intracellular washout of thallium 201 should be preserved as long as irreversible sarcolemmal membrane injury was avoided. To produce myocardial stunning, 19 open-chested dogs with a critical left anterior descending coronary artery (LAD) st...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1988
ISSN: 0735-1097
DOI: 10.1016/0735-1097(88)90381-6